The Efficacy of Taurolidine Citrate Solution v Heparin Lock Solution Instilled in Catheter Lumens of End Stage Renal Disease

Background: Hemodialysis patients with end-stage renal illness use a tunnelled central vein catheter for vascular access. Heparin preservative, in contrast, exhibits inferior antibacterial effects against biofilm and plank tonic bacteria. Aim: To evaluate the effectiveness of taurolidine citrate solution versus heparin lock when infused into lumens hemodialysis illness. Study design: Randomized clinical trial Place duration study: Unit, King Fahad Specialist Hospital, Buraidah, Saudi Arabia from 11th December 2018 to 10th June 2019. Methodology: One hundred fourteen on aged 40-70 years end stage disease Glomerular filtration rate (GFR) less than 15 mL/min, maintenance through dialysis dependent at least 6 months patent catheters were selected randomized two equal groups by using sealed opaque envelopes bearing tag group citrate-taurolidine group. Patients excluded study if they had site infection or an unrelated that was antibiotic therapy positive blood cultures within weeks enrollment. Every time removed, routinely obtained lumen look bacterial colonization. At conclusion six hemodialysis, CRI assessed. All instances infections caused documented. Results: Incidence related occurred 5 (8.8%) who underwent while none patient (0%) taurolidine/citrate suffered infection. This data reveals significantly high incidence (p=0.029) efficacy over Conclusion: Efficacy is superior instilled hemodialysis. Keywords: Catheter, Infection, Renal disease,